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Публикувано на: 24.04.07, 00:07
Mood changes during prednisone bursts in outpatients with asthma.
J Clin Psychopharmacol. 2002; 22(1):55-61 (ISSN: 0271-0749)
Brown ES; Suppes T; Khan DA; Carmody TJ
Departments of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9070, USA. Sherwood.Brown@UTSouthwestern.edu
Corticosteroids, such as prednisone and dexamethasone, are frequently prescribed medications sometimes associated with severe systemic side effects. Currently there are limited data regarding the psychiatric side effects of these medications, although mood changes and even psychoses have been reported. This study was designed to quantify psychiatric changes during brief courses of prednisone in patients with asthma. Outpatients with asthma (N = 32) receiving bursts of prednisone (>40 mg/day) were evaluated before, during, and after corticosteroid therapy by use of the Hamilton Rating Scale for Depression, the Young Mania Scale, the Brief Psychiatric Rating Scale, and the Internal State Scale. A Structured Clinical Interview for DSM-IV disorders was also conducted to examine past psychiatric history. Highly significant increases in the Young Mania Scale and Activation subscale of the Internal State Scale (both measures of mania) were observed with no increase in depression measures during the first 3 to 7 days of prednisone therapy. Mood changes were not correlated with improvement in airway obstruction, suggesting that mood elevations may not be in response to improvement in asthma symptoms. Subjects with past or current symptoms of depression had a significant decrease in depressive symptoms during prednisone therapy compared with those without depression. Some patients with posttraumatic stress disorder reported increases in depression and memories of the traumatic event during prednisone therapy. In summary, statistically significant changes in mood were observed even during brief courses of corticosteroids at modest dosages. The symptoms were primarily manic, not depressive. Persons with depression did not become more depressed during prednisone therapy, and, in fact, some showed improvement.
аз съм свикнала да ми се представят широкомащабни изследвания с доказани резултати когато ползвам каквито и да било източници по медицински въпроси ( но това е на професионално ниво )
в общи линии.
и двете горни статии са обобщение на дъъълги статии и изследвания ,които показвам значителна статическа разлика в поведението на хора ,които са лекувани със стероиди ( не анаболни като за спортистите, а кортикостеоиди.За анаболните има други статии)
и тези разлики са предимно в посока на МАНИЯ ,ЕУФОРИЯ до ПСИХОЗА и ДЕЛИРИУМ.
та.
Искрено се надявам Слави да е на стероиди и затова да се държи така.
На колежката ще кажа...
Мен Слави не ме е питал като е решил да си сподели болката,нали?
а мен може д ане ми се иска да му слушам за болката.
Истинската такава я виждам всеки ден
J Clin Psychopharmacol. 2002; 22(1):55-61 (ISSN: 0271-0749)
Brown ES; Suppes T; Khan DA; Carmody TJ
Departments of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9070, USA. Sherwood.Brown@UTSouthwestern.edu
Corticosteroids, such as prednisone and dexamethasone, are frequently prescribed medications sometimes associated with severe systemic side effects. Currently there are limited data regarding the psychiatric side effects of these medications, although mood changes and even psychoses have been reported. This study was designed to quantify psychiatric changes during brief courses of prednisone in patients with asthma. Outpatients with asthma (N = 32) receiving bursts of prednisone (>40 mg/day) were evaluated before, during, and after corticosteroid therapy by use of the Hamilton Rating Scale for Depression, the Young Mania Scale, the Brief Psychiatric Rating Scale, and the Internal State Scale. A Structured Clinical Interview for DSM-IV disorders was also conducted to examine past psychiatric history. Highly significant increases in the Young Mania Scale and Activation subscale of the Internal State Scale (both measures of mania) were observed with no increase in depression measures during the first 3 to 7 days of prednisone therapy. Mood changes were not correlated with improvement in airway obstruction, suggesting that mood elevations may not be in response to improvement in asthma symptoms. Subjects with past or current symptoms of depression had a significant decrease in depressive symptoms during prednisone therapy compared with those without depression. Some patients with posttraumatic stress disorder reported increases in depression and memories of the traumatic event during prednisone therapy. In summary, statistically significant changes in mood were observed even during brief courses of corticosteroids at modest dosages. The symptoms were primarily manic, not depressive. Persons with depression did not become more depressed during prednisone therapy, and, in fact, some showed improvement.
аз съм свикнала да ми се представят широкомащабни изследвания с доказани резултати когато ползвам каквито и да било източници по медицински въпроси ( но това е на професионално ниво )
в общи линии.
и двете горни статии са обобщение на дъъълги статии и изследвания ,които показвам значителна статическа разлика в поведението на хора ,които са лекувани със стероиди ( не анаболни като за спортистите, а кортикостеоиди.За анаболните има други статии)
и тези разлики са предимно в посока на МАНИЯ ,ЕУФОРИЯ до ПСИХОЗА и ДЕЛИРИУМ.
та.
Искрено се надявам Слави да е на стероиди и затова да се държи така.
На колежката ще кажа...
Мен Слави не ме е питал като е решил да си сподели болката,нали?
а мен може д ане ми се иска да му слушам за болката.
Истинската такава я виждам всеки ден
